Improved Identification of Intracortical Lesions in Multiple Sclerosis with Phase-Sensitive Inversion Recovery in Combination with Fast Double Inversion Recovery MR Imaging

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Improved identification of intracortical lesions in multiple sclerosis with phase-sensitive inversion recovery in combination with fast double inversion recovery MR imaging.

BACKGROUND AND PURPOSE Accurate detection and classification of purely intracortical lesions in multiple sclerosis (MS) are important in understanding their role in disease progression and impact on the clinical manifestations of the disease. However, detection of these lesions with conventional MR imaging remains a challenge. Although double inversion recovery (DIR) has been shown to improve t...

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Improved Identification of Intracortical Lesions in Multiple Sclerosis with Phase-Sensitive Inversion Recovery in Combination with Fast Double Inversion Recovery MRI

F. Nelson A.H. Poonawalla P. Hou F. Huang J.S. Wolinsky P.A. Narayana BACKGROUND AND PURPOSE: Accurate detection and classification of purely intracortical lesions in multiple sclerosis (MS) are important in understanding their role in disease progression and impact on the clinical manifestations of the disease. However, detection of these lesions with conventional MR imaging remains a challeng...

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Double inversion recovery brain imaging at 3T: diagnostic value in the detection of multiple sclerosis lesions.

BACKGROUND AND PURPOSE To prospectively determine the sensitivity in the detection of multiple sclerosis (MS) lesions by using double inversion recovery (DIR), fluid-attenuated inversion recovery (FLAIR), and T2-weighted turbo spin-echo (T2 TSE) MR imaging at 3T. METHODS Seventeen patients presenting with a clinically isolated syndrome (CIS) suggestive of MS, 9 patients with definite MS, and ...

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Detection of cortical inflammatory lesions by double inversion recovery magnetic resonance imaging in patients with multiple sclerosis.

BACKGROUND A significant inflammatory pathologic disorder in the cortex of patients with multiple sclerosis (MS) has been demonstrated by ex vivo studies. OBJECTIVE To determine the frequency, time of appearance, and clinical relevance of intracortical lesions (ICLs) in MS in vivo. DESIGN Double inversion recovery sequence study. SETTING Multiple Sclerosis Centre of the Veneto Region. Pat...

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Enhanced detection of cortical lesions in multiple sclerosis using magnetization transfer and double inversion recovery

Purpose: Multiple sclerosis (MS) has long been considered a pure white matter (WM) disease. In recent years, greater attention is paid to cortical pathology in MS. However, detection of cortical lesions is complicated by low contrast on MRI between lesions and surrounding tissue, the relatively low image resolution, and the confounding signal from WM and cerebrospinal fluid (CSF). Double invers...

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ژورنال

عنوان ژورنال: American Journal of Neuroradiology

سال: 2007

ISSN: 0195-6108,1936-959X

DOI: 10.3174/ajnr.a0645